Biophotonics Laboratory
California Institute of Technology
Welcome

The research of the Biophotonics Laboratory, lead by Professor Changhuei Yang is focused on the development of novel tools that combine optics and microfluidics to tackle diagnostic and measurement problems in biomedicine. The major techniques that are under development in the laboratory include Optofluidic Microscopy (OFM), Turbidity Suppression by Optical Phase Conjugation (TSOPC), and Coherence Domain Probing System.

Optofluidic Microscopy is a unique way of scanning objects without lenses, which can greatly reduce the size and the cost of conventional microscopes. TSOPC probes the elastic optical scattering in biological tissues, which has great potential in biomedical applications such as tissue density heterogeneity determination, photodynamic therapy, etc. Our research on Coherence Domain Probing System is seeking to improve the current Optical Coherence Tomography (OCT) technique for various clinical applications.

Some major research projects are outlined in the column on the right. For more detailed information, please visit our research page. We are also pleased to include a link to the Optofluidics Webpage, which contains information on the collaborative efforts between Caltech, Harvard, Stanford and UCSD to further develop the field of optofluidics.

News

We are currently looking for new post-docs and graduate students. Interested candidates are welcome to contact Dr.Yang. The Biophotonics Lab, get directions, is located in the Moore Laboratory on the main Caltech campus.

Optofluidic Microscopy
Optofluidic Microscopy (OFM) is a new compact and lensless microscopic imaging technique. OFM utilizes microfluidic flow to deliver specimens across array(s) of micrometer-size apertures defined on a metal-coated CMOS sensor to generate direct projection images. Read more...



Turbidity Suppression by Optical Phase Conjugation
Elastic optical scattering in biological tissues typically dominates over absorption by an order of magnitude or more. Elastic optical scattering is a deterministic and time reversible process. By recording the phase and amplitude of the propagating scattered light field and reproducing a back-propagating optical phase conjugate (OPC) field, the light should be able to retrace its trajectory through the scattering medium and return the original input light field. Read more...



Coherence Domain Probing System
We are especially interested in the development of the Optical Coherence Tomography system for clinical applications. The research includes Paired Angle Rotation Scanning OCT (PARS-OCT), Hand-Held Forward-Imaging Needle Endoscope, etc. Read more...