Welcome
The research of the Biophotonics Laboratory, lead by Professor Changhuei
Yang is focused on the development of novel tools that combine optics and
microfluidics to tackle diagnostic and measurement problems in biomedicine.
The major techniques that are under development in the laboratory include
Optofluidic Microscopy (OFM), Turbidity Suppression by Optical Phase
Conjugation (TSOPC), and Coherence Domain Probing System.
Optofluidic Microscopy is a unique way of scanning objects
without lenses, which can greatly reduce the size and the cost of
conventional microscopes. TSOPC probes the elastic optical scattering
in biological tissues, which has great potential in biomedical applications
such as tissue density heterogeneity determination, photodynamic
therapy, etc. Our research on Coherence Domain Probing System is
seeking to improve the current Optical Coherence Tomography (OCT)
technique for various clinical applications.
Some of our major research projects are outlined in the column on the right. For
more detailed information, please visit our research
page. We are also pleased to include a link to the Optofluidics Webpage,
which contains information on the collaborative efforts between Caltech, Harvard, Stanford
and UCSD to further develop the field of optofluidics.
News and Announcements
On March 9, 2011, Guoan Zheng was awarded the Lemelson-MIT Caltech Student Prize for his innovative
development of an on-chip, inexpensive microscopy imaging technology.
Biophotonics Lab Location
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Optofluidic Microscopy
Optofluidic Microscopy (OFM) is a new
compact and lensless microscopic imaging technique. OFM utilizes
microfluidic flow to deliver specimens across array(s) of micrometer-size
apertures defined on a metal-coated CMOS sensor to generate direct
projection images. Read more... |
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Wide Field of View Microscopy
We have developed a new microscopy design that can achieve wide field-of-view (FOV) imaging and yet possesses a resolution that is comparable to a conventional microscope. This technology is scalable and represents a cost-effective way to implement wide FOV microscopy systems.
Read more... |
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Turbidity
Suppression by Optical Phase Conjugation
Elastic optical scattering is a deterministic
and time reversible process. By recording the phase and
amplitude of the propagating scattered light field and reproducing
a back propagating optical phase conjugate (OPC) field, the
light can retrace its trajectory through the
scattering medium and return the original input light field.
Read more... |
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Coherence
Domain Probing System
We are especially interested in the
development of an Optical Coherence Tomography system for
clinical applications. This research includes the Paired Angle Rotation
Scanning OCT (PARS-OCT), Hand-Held Forward-Imaging Needle Endoscope,
etc. Read more... |
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ePetri Dish Project
The ePetri dish is a chip-scale lensfree microscopy platform that can automatically perform high resolution (~0.66 micron) microscopy imaging over a large field-of-view (6mm × 4mm). Read more... |
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