Biophotonics Laboratory
California Institute of Technology


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Yan LiuYan Liu

Electrical Engineering
Postdoctoral Scholar
MC 136-93
Moore Lab 244
Lab Phone (626) 395-2231
Postdoc Office Moore 229
Office Phone (626) 395-3077


Ph.D., Washington University, USA, 2016
B.S., Tsinghua University, China, 2010

Research Interests

I am interested in developing techniques for deep-tissue optical focusing and imaging. During my PhD study in Prof. Lihong V. Wang’s group, I developed optical phase conjugation based wavefront shaping techniques, including time-reversed ultrasonically encoded (TRUE) optical focusing and time-reversed adapted perturbation (TRAP) optical focusing, to focus light deep inside biological tissue for noninvasive high-resolution imaging, optical manipulation, and phototherapy. I also had experience in photoacoustic imaging, ultrasound-modulated optical tomography/acousto-optic imaging, and fluorescence imaging.

Publications (as of 2/20/2017, [ ] denotes co-first authors)

1. Y. Liu, C. Ma, Y. Shen, J. Shi and L. V. Wang, "Focusing light inside dynamic scattering media with millisecond digital optical phase conjugation," Optica 4(2), 280-288 (2017).
2. [Y. Shen, Y. Liu], C. Ma, and L. V. Wang, "Sub-Nyquist sampling boosts targeted light transport through opaque scattering media," Optica 4, 97-102 (2017).
3. [Y. Shen, Y. Liu], C. Ma, and L. V. Wang, "Focusing light through biological tissue and tissue-mimicking phantoms up to 9.6 centimeters in thickness with digital optical phase conjugation," Journal of Biomedical Optics 21(8), 085001 (2016).
4. Y. Liu, C. Ma, Y. Shen, and L. V. Wang, "Bit-efficient, sub-millisecond wavefront measurement using a lock-in camera for time-reversal based optical focusing inside scattering media," Optics Letters, 41, 1321-1324 (2016).
5. Y. Liu, Y. Shen, C. Ma, J. Shi, and L. V. Wang, "Lock-in camera based heterodyne holography for ultrasound-modulated optical tomography inside dynamic scattering media," Applied Physics Letters, 108, 231106 (2016).
6. [Y. Shen, Y. Liu], C. Ma, and L. V. Wang, "Focusing light through scattering media by full-polarization digital optical phase conjugation," Optics Letters, 41, 1130-1133 (2016).
7. [Y. Liu, P. Lai], C. Ma, X. Xu, A. Grabar, and L. V. Wang, "Optical focusing deep inside dynamic scattering media with near-infrared time-reversed ultrasonically encoded (TRUE) light," Nature Communications 6 (2015).
8. Y. Liu, C. Zhang, and L. V. Wang, "Effects of light scattering on optical-resolution photoacoustic microscopy," Journal of Biomedical Optics 17(12), 126014 (2012).
9. C. Ma, F. Zhou, Y. Liu, and L. V. Wang, "Single-exposure optical focusing inside scattering media using binarized time-reversed adapted perturbation," Optica 2, 869-876 (2015).
10. C. Ma, X. Xu, Y. Liu, and L. V. Wang, "Time-reversed adapted-perturbation (TRAP) optical focusing onto dynamic objects inside scattering media," Nature Photonics 8(12), 931-936 (2014).
11. L. Gao, A. Garcia, Y. Liu, C. Li, and L. V. Wang, "Photobleaching imprinting microscopy: seeing clearer and deeper," Journal of Cell Science 127(2), 288-294 (2014).
12. C. Li, L. Gao, Y. Liu, and L. V. Wang, "Optical sectioning by wide-field photobleaching imprinting microscopy," Applied Physics Letters 103(18) (2013).
13. J. Xia, A. Danielli, Y. Liu, L. Wang, K. Maslov, and L. V. Wang, "Calibration-free quantification of absolute oxygen saturation based on the dynamics of photoacoustic signals," Optics Letters 38(15), 2800-2803 (2013).
14. L. Gao, L. Wang, C. Li, Y. Liu, H. Ke, C. Zhang, and L. V. Wang, "Single-cell photoacoustic thermometry," Journal of Biomedical Optics 18(2), 026003 (2013).
15. M. R. N. Avanaki, A. G. Podoleanu, J. B. Schofield, C. Jones, M. Sira, Y. Liu, and A. Hojjat, "Quantitative evaluation of scattering in optical coherence tomography skin images using the extended Huygens-Fresnel theorem," Applied Optics 52(8), 1574-1580 (2013).