Biophotonics Laboratory
California Institute of Technology


Fourier Ptychographic Microscopy (FPM)
ePetri Dish Project
Optofluidic Microscopy (OFM)
Wide Field of View Microscopy (WFOV)
Turbidity Suppression by Optical Phase Conjugation in Biological Media
Coherence Domain Probing Systems


Coherence Domain Probing Systems

The development of various endoscopic OCT probes has greatly extended the application range of this high-resolution biomedical imaging technique. One of our research interest is a new design for a forward-imaging OCT needle probe – the Paired Angle Rotation Scanning OCT (PARS-OCT) probe. Based on our PARS technology, we developed the hand-held forward-imaging optical coherence tomography (OCT) needle endoscope system. The feasibility of retinal imaging has been tested on enucleated ex vivo porcine eyes, where structural features including remnant vitreous humor, retina, and choroid can be clearly distinguished. The narrow probe can easily fit through the standard cannula or scleral incisions employed in ophthalmic surgery. The probe can potentially serve as a better alternative to traditional visual inspection by white-light illumination during vitreoretinal surgery (e.g. vitrectomy).

The figure above illustrates OCT and SEM images of human cadaver eye tissue segments: (a) OCT image of a tissue segment with TM intact, acquired by translating the stage. (b) OCT image of a tissue with TM removed, acquired by rotating the needles of the endoscopic probe. (c) SEM image of the same CC in (b). O, CC opening; T, CC path through sclera.