Biophotonics Laboratory
California Institute of Technology


Fourier Ptychographic Microscopy (FPM)
ePetri Dish Project
Optofluidic Microscopy (OFM)
Wide Field of View Microscopy (WFOV)
Turbidity Suppression by Optical Phase Conjugation in Biological Media
Coherence Domain Probing Systems


Microfluidic long-term culture, manipulation and imaging platform for C. elegans

(Primary student researchers: Xiquan Cui, Lap Man Lee)

In this project, we aim to develop a novel microfluidic tool to confine and sustain a biological sample in an enclosed environment. Bioscientist can use such a tool to monitor and observe the development of a biological sample under the influence of different stimulations. At this stage, we can trap a single C. elegans; feed it with bacteria and special reagent; and immobilize it for high resolution DIC and fluorescent imaging.

Figure 1. Trapping a single C. elegans.

Figure 2. High resolution DIC (a) and corresponding fluorescent (b,c) images of C. elegans (at different focal depths) immobilized by our new microfluidic tool.