Peer-Reviewed Publications

2010

34. Meng Cui and Changhuei Yang, Implementation of a digital optical phase conjugation system and its application to study the robustness of turbidity suppression by phase conjugation; Optics Express Vol 18 (4), 3444-3455 (2010) doi:10.1364/OE.18.003444 (pdf)

33. Shuo Pang, Xiquan Cui, John DeModena, Ying Min Wang, Paul Sternberg and Changhuei Yang; Implementation of a color-capable optofluidic microscope on a RGB CMOS color sensor chip substrate; Lab on a Chip Vol 10, 411-414 (2010) doi: 10.1039/b919004j (pdf)

32. Meng Cui, Emily J. McDowell, and Changhuei Yang; An in vivo study of turbidity suppression by optical phase conjugation (TSOPC) on rabbit ear; Optics Express Vol 18 (1), 25-30 (2010)
doi:10.1364/OE.18.000025 (pdf)

2009

31. Ying Min Wang, Guoan Zheng, and Changhuei Yang; Characterization of acceptance angles of small circular apertures; Optics Express Vol 17 (26), 23903–23913 (2009) (pdf)
PMID: 20052101 [PubMed - in process]

30. Jian Ren, Jigang Wu, Emily J. McDowell, and Changhuei Yang; Manual-scanning optical coherence tomography probe based on position tracking; Optics Letters Vol 34 (21), 3400-3402 (2009) doi:10.1364/OL.34.003400 (pdf) PMID: 19881607

29. Meng Cui, Emily J. McDowell, and Changhuei Yang; Observation of polarization-gate based reconstruction quality improvement during the process of turbidity suppression by optical phase conjugation; Applied Physics Letters Vol 95 (12), 123702 (2009) doi:10.1063/1.3236836 (pdf)
PMID: 19859580; PMCID: PMC2766401

28. Lap Man Lee, Xiquan Cui and Changhuei Yang; The Application of on-chip Optofluidic Microscopy for Imaging Giardia lamblia Trophozoites and Cysts; Biomedical Microdevices Vol 11 (5), 951-958 (Oct 2009)
doi 10.1007/s10544-009-9312-x (pdf) PMID: 19365730

27. Guoan Zheng, Xin Heng and Changhuei Yang; A Phase Conjugate Mirror Inspired Approach for Building Cloaking Structures with Left-handed Materials; New Journal of Physics Vol 11, 033010-25 (2009) (pdf)
NIHMSID: 112152

2008

26. Jigang Wu, Xiquan Cui, Lap Man Lee, and Changhuei Yang; The application of Fresnel zone plate based projection in optofluidic microscopy; Optics Express Vol 16 (20), 15595-602 (2008) (pdf)
PMID: 18825198; NIHMSID: 112147; PMCID: PMC2688452

25. Xiquan Cui, Matthew Lew, and Changhuei Yang; Quantitative differential interference contrast microscopy based on structured-aperture interference; Applied Physics Letters Vol 93 (9), 091113 (2008) NIHMSID: 111214 (pdf)

24. Xiquan Cui, Lap Man Lee, Xin Heng, Weiwei Zhong, Paul W. Sternberg, Demetri Psaltis, and Changhuei Yang; Lensless high-resolution on-chip optofluidic microscopes for Caenorhabditis elegans and cell imaging; Proceedings of the National Academy of Science Vol 105 (31), 10670 (2008) (pdf)
PMID: 18663227; PMCID: PMC2488383; NIHMSID: 111267

23. Zahid Yaqoob, Demetri Psaltis, Michael S. Feld, and Changhuei Yang; Optical phase conjugation for turbidity suppression in biological samples; Nature Photonics Vol 2 (2), 110 (2008) (pdf)
PMID: 19492016; PMCID: PMC2688902

22. Shuo Han, Marinko V. Sarunic, Jigang Wu, Mark Humayun, and Changhuei Yang; Handheld forward-imaging needle endoscope for ophthalmic optical coherence tomography inspection; Journal of Biomedical Optics Vol 13 (2), 020505 (2008) (pdf) PMID: 18465947

21. Emily J. McDowell, Jian Ren, and Changhuei Yang; Fundamental sensitivity limit imposed by dark 1/f noise in the low optical signal detection regime; Optics Express Vol 16 (10), 6822 (2008) (pdf)
PMID: 18545385

2007

20. Jigang Wu, Zahid Yaqoob, Xin Heng, Lap Man Lee, Xiquan Cui, and Changhuei Yang; Full field phase imaging using a harmonically matched diffraction grating pair based homodyne quadrature interferometer; Applied Physics Letters Vol 90 (15), 151123 (2007) (pdf)

19. Emily J. McDowell, Xiquan Cui, Zahid Yaqoob, and Changhuei Yang; A generalized noise variance analysis model and its application to the characterization of 1/f noise; Optics Express Vol 15 (7), 3833 (2007) (pdf)
PMID: 19532627

18. Emily J. McDowell, Marinko V. Sarunic, Zahid Yaqoob, and Changhuei Yang; SNR enhancement through phase dependent signal reconstruction algorithms for phas separated interferometric signals; Optics Express Vol 15 (16), 10103 (2007) (pdf) PMID: 19547360

17. Jeff Fingler, Dan Schwartz, Changhuei Yang, and Scott E. Fraser; Mobility and transverse flow visualization using phase variance contrast with spectral domain optical coherence tomography; Optics Express Vol 15 (20), 12653 (2007) (pdf) PMID: 19550532

16. Guoan Zheng, Lixin Ran, and Changhuei Yang; Electromagnetic equivalent model for phase conjugate mirror based on the utilization of left-handed material; Optics Express Vol 15 (21), 13877 (2007) (pdf)
PMID: 19550659

15. Matthew Lew, Xiquan Cui, Xin Heng, and Changhuei Yang; Interference of a four-hole aperture for on-chip quantitative two-dimensional differential phase imaging; Optics Letters Vol 32 (20), 2963 (2007) (pdf)
PMID: 17938667

14. David T. Raphael, Changhuei Yang, Nancy Tresser, Jigang Wu, Yaoping Zhang, and Linda Rever; Images of Spinal Nerves and Adjacent Structures With Optical Coherence Tomography: Preliminary Animal Studies; The Journal of Pain Vol 8 (10), 767 (2007) (pdf) PMID: 17586098

13. Snow H. Tseng and Changhuei Yang; 2-D PSTD Simulation of optical phase conjugation for turbidity suppression; Optics Express Vol 15 (24), 16055 (2007) (pdf) PMID: 19550887

12. Xin Heng, Edward Hsiao, Demetri Psaltis, and Changhuei Yang; An optical tweezer actuated, nanoaperture-grid based Optofluidic Microscope implementation; Optics Express Vol 15 (25), 16367 (2007) (pdf) PMID: 19550927

11. Jigang Wu, Zahid Yaqoob, Xin Heng, Xiquan Cui, and Changhuei Yang; Harmonically matched grating-based full-field quantitative high-resolution phase microscope for observing dynamics of transparent biological samples; Optics Express Vol 15 (26), 18141 (2007) (pdf) PMID: 19551112

2006

10. Jigang Wu, Michael Conry, Chunhui Gu, Fei Wang, Zahid Yaqoob, and Changhuei Yang; Paired-angle-rotation scanning optical coherence tomography forward-imaging probe; Optics Letters Vol 31 (9), 1265 (2006) (pdf) PMID: 16642080

9. Zahid Yaqoob, Jeff Fingler, Xin Heng, and Changhuei Yang; Homodyne en face optical coherence tomography; Optics Letters Vol 31 (12), 1815 (2006) (pdf) PMID: 16729080

8. Demetri Psaltis, Steven Quake, and Changhuei Yang; Developing optofluidic technology through the fusion of microfluidics and optics; Nature Vol 442 (7101), 381 (2006) (pdf) PMID: 16871205

7. Xin Heng, David Erickson, Larry R. Baugh, Zahid Yaqoob, Paul W. Sternberg, Demetri Psaltis, and Changhuei Yang; Optofluidic microscopy: A Method for Implementing High Resolution Optical Microscope On A Chip; Lab on a Chip Vol 6 (10), 1274 (2006) (pdf) PMID: 17102839

6. Xiquan Cui, Xin Heng, Jigang Wu, Zahid Yaqoob, Axel Scherer, Demetri Psaltis, and Changhuei Yang; Slanted Hole Array Beam Profiler (SHArP) - A high resolution on-chip beam profiler based on a linear aperture array; Optics Letters Vol 31 (21), 3161 (2006) (pdf) PMID: 17041668

5. Zahid Yaqoob, Jigang Wu, Xiquan Cui, Xin Heng, and Changhuei Yang; Harmonically-related diffraction gratings-based interferometer for quadrature phase measurements; Optics Express Vol 14 (18), 8127 (2006) (pdf) PMID: 19529185

4. Zahid Yaqoob, Emily McDowell, Jigang Wu, Jeff Fingler, Xin Heng, and Changuei Yang; Molecular contrast optical coherence tomography: A pump-probe scheme using indocyanine green as a contrast agent; Journal of Biomedical Optics Vol 11 (5), 054017 (2006) (pdf) PMID: 17092166

3. Zahid Yaqoob, Jigang Wu, Emily J. McDowell, Xin Heng, and Changhuei Yang; Methods and application areas of endoscopic optical coherence tomography; Journal of Biomedical Optics Vol 11 (6), 063001 (2006) (pdf)
PMID: 17212523

2. Xin Heng, Xiquan Cui, David W. Knapp, Jigang Wu, Zahid Yaqoob, Emily J. McDowell, Demetri Psaltis, and Changhuei Yang; Theoretical modeling and experimental characterization of the collection of light through a nanoaperture from a point source; Optics Express Vol 14 (22), 10410 (2006) (pdf)
PMID: 19529440

2005

1. Changhuei Yang; Molecular contrast optical coherence tomography: A review; Photochemistry and Photobiology Vol 81 (2), 215 (2005) (pdf) PMID: 15588122; PMCID: PMC1283114

Books

2. Yeshaiahu Fainman, Luke Lee, Demetri Psaltis, and Changhuei Yang; Optofluidics: Fundamentals, Devices, and Applications (Biophotonics) published by McGraw-Hill, 2009 (ISBN-13: 978-0071601566) 1. Changhuei Yang, Xin Heng, Xiquan Cui and Demetri Psaltis, Ch. 10: Optofluidic Microscope - Fitting a Microscope Onto a Sensor Chip in CMOS Biotechnology edited by Hankho Lee, Donhee Ham, Robert M. Westervelt, published by Springer, 2007 (ISBN-13: 978-0387368368)

News Articles

2009

5.The most transparent research, by Melinda Wenner, Nature Medicine 15, 1106 - 1109 (2009), doi:10.1038/nm1009-1106. (pdf) http://www.nature.com/nm/journal/v15/n10/full/nm1009-1106.html

4. Microscopic marvels: Microscope for the masses, by Erika Check Hayden, Nature Vol 459, June 4, 2009, pp. 632-633. (pdf) http://www.nature.com/news/2009/090603/full/459632a.html

3. A Toymaker’s Lab, by Marcus Y. Woo. Engineering & Science, Spring 2009, pp. 22-27. (pdf)

2. The $10 Microscope, by Taylor Buley. 2009 Forbes.com, LLC. http://www.forbes.com/2009/02/06/microscopes-semicondutors-sciences-technology-sciences_0206_microscope.html

1. Optofluidics: Optofluidics Enhances Cytometry, by Changhuei Yang, David Erickson, and Demetri Psaltis, Bio Optics World, January 2009. http://www.bioopticsworld.com/display_article/350048/131/none/none/Featu/OPTOFLUIDICS:-Optofluidics--enhances-cytometry

2008

11. Microscope-On-a-Chip Is One Step Closer to the Tricorder, by Dave Bullock. WIRED, October 13, 2008.
http://www.wired.com/science/discoveries/multimedia/2008/10/gallery_scope_chip

10. Mini-Microscope Could Lead to Cell-Sorting Implants, by Alexis Madriga. WIRED, July 28, 2008.
http://www.wired.com/wiredscience/2008/07/mini-microscope

9. New Micro-Microscope Is Portable And Cheap, National Public Radio Interview: Talk of the Nation, August 2008.
http://www.npr.org/templates/story/story.php?storyId=93158270

8. Microscope-on-a-Chip Is Small in Size, Big in Scope, by Shana Leonard. Medical Product Manufacturing News, October 2008. (pdf)

7. Caltech Bioengineers Develop "Microscope on a Chip", Caltech news releases, July 2008.
http://mr.caltech.edu/media/Press_Releases/PR13169.html

6. Bringing Microscopes Down to Size in Quest for More Compact Labs, by Henry Fountain. New York Times, July 2008.
http://www.nytimes.com/2008/07/29/science/29obscop.html?_r=1&scp=1&sq=changhuei%20&st=cse&oref=slogin

5. Lensless On-Chip Microscope Inspired by "Floaters" in the Eye, by J. R. Minkel. Scientific American, July 2008.
http://www.sciam.com/article.cfm?id=lensless-microscope-on-chip-floaters

4. Tiny $10 Microscope -- A high-resolution, lens-free microscope fits on a dime-size chip, by Katherine Bourzac. Technology Review, June 2008.
http://www.technologyreview.com/Biotech/21147/?a=f

3. Optofluidics Emerges from the Laboratory, by David Erickson, Cornell University, Changhuei Yang, California Institute of Technology, and Demetri Psaltis, Ecole Polytechnique Federale de Lausanne. Photonics Spectra, February 2008, pp. 74-79. (pdf)

2. Gaining High Resolution with Nanoaperture Grid, by Hank Hogan. Photonics Spectra, February 2008, pp. 103. (pdf)

1. Getting in Deeper, by Hank Hogan. Biophotonics, July 2008, pp. 25. (pdf)

2007

3. Building a Microscopic Microscope, by Changhuei Yang and Demetri Psaltis. EAS ENGenious - Progress Report, Spring 2007, pp.44-47. (pdf)

2. PARS-OCT Endoscopy System, by Marinko Sarunic, Shuo Han, Jigang Wu, Zahid Yaqoob, Changhuei Yang. Thorlabs

1. Gradient Index Optical Microsystems Visualize Living Cells in Deep Tissue, by Dr. Bernhard Messerschmidt, Grintech GmbH. Biophotonics International, September 2007, pp. 36-38. (pdf)

2006

4. Caltech Researchers Announce Invention of the Optofluidic Microscope, Caltech Media Relations, September 5, 2006. (Press Release)

3. Optofluidics Reinvents the Microscope, by Changhuei Yang, Xin Heng and Demetri Psaltis. Laser Focus World Vol 42 (12), December 2006, pp. 83-86. (pdf)

2. Optofluidics can create small, cheap biophotonic devices, by Changhuei Yang and Demetri Psaltis. Laser Focus World Vol 42 (6), July 2006, pp. 85-88. (pdf)

1. Optofluidic Microscope Enables Lensless Imaging of Microorganisms, Biophotonics International Vol 13 (10), October 2006, pp. 24. (pdf)

Pre-Group Publications

27. Kyungwon An, Changhuei Yang, Ramachandra R. Dasari, and Michael S. Feld, Cavity ring-down technique and its application to measurement of ultraslow velocities, Optics Letters Vol 20, 1068 (1995)

26. Changhuei Yang, and Kyungwon An, Quantum trajectory analysis of a thresholdlike transition in the microlaser, Physical Review A Vol 55, 4492 (1997)

25. Changhuei Yang, Kyungwon An, Lev T. Perelman, Ramachandra R. Dasari, and Michael S. Feld, Spatial coherence of forward-scattered light in a turbid medium, Journal of the Optical Society of America A Vol 16, 866 (1999)

24. Changhuei Yang, Kyungwon An, Lev T. Perelman, Adam Wax, Ramachandra R. Dasari, and Michael S. Feld, Feasibility of field-based light scattering spectroscopy, Journal of Biomedical Optics Vol 5, 138 (2000)

23. Changhuei Yang, Adam Wax, Irene Georgakoudi, Eugene B. Hanlon, Kamran Badizadegan, Ramachandra R. Dasari, Michael S. Feld, Interferometric phase dispersion microscopy, Optics Letters Vol 25, 1526 (2000) (pdf)

22. Changhuei Yang, Adam Wax, Michael S. Feld, Measurement of anomalous phase velocity of ballistic light in a random medium using a novel interferometer, Optics Letters Vol 26, 235 (2001) (pdf)

21. Changhuei Yang, Adam Wax, Ramachandra R. Dasari, Michael S. Feld, Phase dispersion optical tomography, Optics Letters Vol 26, 686 (2001) (pdf)

20. Changhuei Yang, Adam Wax, Mariah Hahn, Kamran Badizadegan, Ramachandra R. Dasari, Michael S. Feld, The study of sub-wavelength and sub-Hertz cellular dynamics using a novel phase referenced interferometer, Optics Letters Vol 26, 1271 (2001) (pdf)

19. Adam Wax, Changhuei Yang, Ramachandra R. Dasari, Michael S. Feld, Measurement of angular distributions using low-coherence interferometry for lightscattering spectroscopy, Optics Letters Vol 26, 322 (2001)

18. Adam Wax, Changhuei Yang, Ramachandra R. Dasari, Michael S. Feld, Path-length-resolved dynamic light scattering: modeling the transition from single to diffusive scattering, Applied Optics Vol 40, 4222 (2001)

17. Changhuei Yang, Adam Wax, Ramachandra R. Dasari, Michael S. Feld, 2<pi> ambiguity-free optical depth ranging with sub-nanometer precision using a novel phase-crossing low coherence interferometer, Optics Letters Vol 27 (2), 77 (2002) (pdf) PMID: 18007717

16. Adam Wax, Changhuei Yang, Vadim Backman, Maxim Kalashnikov, Ramachandra R. Dasari, and Michael S. Feld, Determination of particle size using the angular distribution of backscattered light as measured with low-coherence interferometry, Journal of the Optical Society of America A Vol 19 (4), 737 (2002); PMID: 11934166

15. Adam Wax, Changhuei Yang, Vadim Backman, Kamran Badizadegan, Charles W. Boone, Ramachandra R. Dasari, Michael S. Feld, Cellular organization and sub-structure measured using angle-resolved low coherence interferometry, Biophysical Journal Vol 82 (4), 2256 (2002); PMID: 11916880; PMCID: PMC1302018

14. Changhuei Yang, Jerome Mertz, Transmission confocal laser scanning microscopy with a virtual pinhole based on nonlinear detection, Optics Letters Vol 28, 224 (2003) (pdf)

13. Adam Wax, Changhuei Yang, Markus G. Müller, Ronald Nines, Charles W. Boone, Vernon E. Steele, Gary D. Stoner, Ramachandra R. Dasari and Michael S. Feld, In Situ detection of neoplastic transformation and chemopreventive effects in rat esophagus epithelium using angle-resolved low-coherence interferometry, Cancer Research Vol 63 (13), 3556 (2003); PMID: 12839941

12. Adam Wax, Changhuei Yang, and Joseph Izatt, Fourier-domain low coherence interferometry for light-scattering spectroscopy, Optics Letters Vol 28 (14), 1230 (2003); PMID: 12885030

11. Michael Choma, Marinko Sarunic, Changhuei Yang, Joseph Izatt, Sensitivity advantage of swept source and Fourier domain optical coherence tomography, Optics Express Vol 11, 2183 (2003) (pdf)
PMID: 19466106

10. Michael Choma, Changhuei Yang, Joseph Izatt, Instantaneous quadrature low-coherence interferometry with 3x3 fiber-optic couplers, Optics Letters Vol 28 (22), 2162 (2003) (pdf) PMID: 14649928

9. Changhuei Yang, Siavash Yazdanfar, Joseph Izatt, Amplification of optical delay by use of matched linearly chirped fiber Bragg gratings, Optics Letters Vol 29 (7), 685 (2004) (pdf) PMID: 15072358

8. Changhuei Yang, Michael Choma, Laura Lamb, John Simon, Joseph Izatt, Protein based molecular contrast OCT with phytochrome as the contrast agent, Optics Letters Vol 29 (12), 1396 (2004) (pdf) PMID: 15233447

7. Changhuei Yang, Michael Choma, Brian Applegate, John Simon, Joseph Izatt, Spectral triangulation molecular contrast OCT with indocyanine green as the contrast agent, Optics Letters Vol 29 (17), 2016 (2004) (pdf) PMID: 15455765; PMCID: PMC1283115

6. Brian Applegate, Changhuei Yang, Andrew Rollins, Joseph Izatt, Polarization resolved second harmonic generation optical coherence tomography in collagen, Optics Letters Vol 29 (19), 2252 (2004)
PMID: 15524371

5. Marinko V. Sarunic, Michael A. Choma, Changhuei Yang, Joseph A. Izatt, Instantaneous complex spectral domain OCT using 3x3 fiber couplers, Optics Express Vol 13, 957 (2005) PMID: 19494959

4. Siavash Yazdanfar, Changhuei Yang, Marinko V. Sarunic, Joseph A. Izatt, Frequency estimation precision in Doppler optical coherence tomography using the Cramer-Rao lower bound, Optics Express Vol 13, 410 (2005) PMID: 19488367

3. Andrew Ahn, Changhuei Yang, Adam Wax, Gabriel Popescu, Chris Fang-Yen, Kamran Badizadegan, Ramachandra Dasari, Michael Feld, Harmonic phase-dispersion microscope with a Mach-Zehnder interferometer, Applied Optics Vol 44 (7), 1188-90 (2005) PMID: 15765698

2. Brian E. Applegate, Changhuei Yang, Joseph A. Izatt, Theoretical comparison of the sensitivity of molecular contrast optical coherence tomography techniques, Optics Express Vol 13, 8146-63 (2005) PMID: 19498844

1. Michael. A. Choma, Audrey K. Ellerbee, Changhuei Yang, Joseph A. Izatt, Spectral-domain phase microscopy, Optics Letters Vol 30 (10), 1162-64 (2005) PMID: 15945141